High throughput ANI analysis of 90K prokaryotic genomes reveals clear species boundaries
نویسندگان
چکیده
منابع مشابه
Evolution of prokaryotic genomes.
Molecular genetics, which has its roots mainly in the development of microbial genetics in the middle of this century, not only greatly facilitates investigations of essential cellular functions, but also offers a means to better understand evolutionary progress. Spontaneous mutagenesis, the driving force of biological evolution, depends on a multitude of mechanistically distinct processes, man...
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As revealed by genome sequencing, the biology of prokaryotes with reduced genomes is strikingly diverse. These include free-living prokaryotes with ∼800 genes as well as endosymbiotic bacteria with as few as ∼140 genes. Comparative genomics is revealing the evolutionary mechanisms that led to these small genomes. In the case of free-living prokaryotes, natural selection directly favored genome ...
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Genomes contain many perfect and approximate tandem repeats (TRs) which are two or more adjacent similar DNA sequences of a certain length and are products of tandem duplication. Duplication generally requires small non-duplicated repeats as primers [1]. Present techniques for finding TRs are divided into fully automated techniques such as the Tandem Repeats Finder (TRF) [2], TROLL and Sputnik,...
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The availability of over 1500 completely sequenced and annotated prokaryotic genomes offers a variety of comparative and predictive approaches on genome-scale. The results of such analyses strongly rely on the quality of the employed data and the computational strategy of their interpretation. Today, comparative genomics allows for the quick and accurate assignment of genes and often their corr...
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ژورنال
عنوان ژورنال: Nature Communications
سال: 2018
ISSN: 2041-1723
DOI: 10.1038/s41467-018-07641-9